Sentence examples for most miRNA binding from inspiring English sources

For a given gene with multiple predicted transcripts from RNA22, the transcript with the most miRNA binding sites was chosen.

Strikingly, IGF-IRb [GenBank: AY144592] had the most miRNA binding sites; 13 sites targeted by 12 miRNAs.

Most miRNA binding sites lie within the 3' UTR, although there are some reports of miRNAs binding in the 5' UTR and coding region of mRNAs [ 21, 22].

Among these putative targets, CDK6, CTNNBIPI, TOB1, and HDAC4 contained the most predicted miRNA binding sites, whereas DUSP2, TGFB3, and SMAD6 each contained a solitary putative miR-29b target site.

However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure.

Each miRNA species regulates multiple genes, and most mRNAs contain multiple miRNA binding sites within their 3'-UTR, suggestive of a complex regulatory network [9].

The majority of on-line pieces of software predict miRNA target sites only in the 3′UTR, and most of the characterised miRNA binding sites occur in this region [ 16].

PITA targets are separated into top targets, which are the most likely to be functional miRNA binding sites, or can be expanded to include all predicted miRNA targets.

However, most circRNAs have less than 10 miRNA binding sites (Jeck and Sharpless, 2014) and may not be effective miRNA sponges.

MiRNA target genes were mostly predicted through bioinformatics software, and miRNA binding sites in most species are in 3′-untranslated regions of the target gene.

This leads to more versatility in miRNA regulation of specific targets and, more importantly, may fail to be predicted by the most common algorithms designed to detect miRNA binding sites in the 3' UTR [ 11].