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MiR-1246 was the most markedly elevated in ESCC patients.
MiR-1246 was the most markedly elevated of these miRNAs.
We also analysed the data with regard to grade of disease: HAI-1 and midkine are both most markedly elevated in higher-grade disease.
Notably, CSF IL-6 was also most markedly elevated in ACS, where CSF anti-NR2 levels were the highest (data not shown).
Thus miR-1246 was the most markedly elevated miRNA in ESCC patients and was proved to be an independent poor prognostic factor (Takeshita et al, 2013).
In a recent proteomic study of pulmonary tissue, SP-A was found to be one of the most markedly elevated spots when investigated by two dimensional electrophoresis, i.e. its presence in the spots was confirmed by mass spectrometry [ 8].
Similar(54)
Arsenic was markedly elevated in most children (25), in comparison with values reported in German children (44).
In contrast, exposure to the congeners PCB 138, 153 and 180 was not markedly elevated and most likely associated with general background exposure including food.
As fragments of polymerized fibrinogen such as D-dimer are markedly elevated in most inflammatory states [ 4- 8], it is of particular interest to determine whether these molecules are able to influence cardiac physiology through interaction with ICAM-1.
COX-2 gene expression and its mRNA and protein levels were markedly elevated in most human colorectal cancers relative to adjacent normal mucosa (Kargman et al, 1995; Sano et al, 1995).
CRP levels were measured semiquantitatively and graded negative, detectable, elevated, and markedly elevated.
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