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We chose 2 cell lines displaying the most marked decrease in PHD3 expression, MB-435 and PC-3, and 2 cell lines displaying moderate to high basal PHD3 expression, MCF7 and DU 145 for treatment with 5-Aza-dC.
Most marked decrease of AR age occurred in children with highest weight.
After ovine lateral meniscectomy, the most marked decrease in PRG4 expression was observed in the lateral compartment with the most severe histopathological alterations.
As expected, cyclin D1 showed a significant decrease in protein levels in those groups in which we also obtained a most marked decrease in cell proliferation- 1(d)).
The most marked decrease in patient satisfaction noted here was in the group over 64, who tend to have multiple diseases in long-term conditions – and also an increased need of health services.
Comparison of postoperative BMD measurements with baseline data obtained immediately after surgery showed substantial bone loss in the proximal periprosthetic regions, with the most marked decrease in BMD being observed in Gruen zones 6 and 7 one year after surgery.
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[D-Ala2,N-MePhe4,Gly-ol5] enkephalin (DAMGO, a selective μ-opioid receptor agonist) microinjection into the dorsomedial hypothalamus (DMH) elicited the most marked Tb decrease than other sites such as the preoptic area (PO), anterior hypothalamus (AH), lateral hypothalamus (LH), ventromedial hypothalamus and posterior hypothalamus (PH).
There was a significant change in combined ER/PR receptor status over time, most notably a marked decrease in the percentage of tumours that had the poor prognostic ER-negative/PR-negative status.
Histological analysis of each of the cell types that constitute the intestinal epithelium, revealed most notably a marked decrease in the number of Alcian Blue positive goblet cells, an altered distribution of Paneth cells and reduced enteroendocrine cells (Supplementary Figure 3).
An increasing tailing of the band at Δν=1381 cm−1 (CF2 symmetric stretching fundamental) has been identified as the most marked effect of decreased crystallinity.
Early June can still be wet, but most years see a marked decrease in rainfall during June and early July.
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