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Glioblastoma multiforme (GBM) is the most common and most malignant primary brain tumor in adulthood [19], [20].
Glioblastoma multiforme (GBM) is both the most common and the most malignant primary brain tumor in adults.
Even in the most malignant primary tumor not all cells have the capability of successfully colonizing at a distant site [5].
In fact, such aberrant vascular proliferation characterized by glomeruloid and garland-like patterns are a hallmark of glioblastoma [1], the most malignant primary brain tumor.
The cancer stem cell (CSC) hypothesis posits that neoplastic clones are exclusively maintained by a small fraction of cells with stem cell properties in many tumors including glioblastoma multiforme (GBM), the most malignant primary brain tumor (glioma) [1].
Glioblastoma multiforme (GBM) is the most malignant primary brain tumor in adults.
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Glioblastoma multiforme (GBM) (WHO grade IV) is the most common and most aggressive malignant primary brain tumor.
Importantly, none of those studies involved the investigation of combined VEGF and Ang‐2 therapy in GBM, the most common and most aggressive malignant primary brain tumor in humans.
The grade III and the grade IV tumors are highly malignant and are, respectively, exemplified by anaplastic astrocytoma and glioblastoma multiforme (GBM), which is the most common and most aggressive malignant primary brain tumor in humans.
Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor in adults and is among the most aggressive of all human tumors.
Glioblastoma multiforme (GBM) is the most malignant human primary brain tumor, and its infiltrative nature represents the leading cause for the failure of therapies and tumor recurrences.
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