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Glioblastoma multiforme (GBM) is the most malignant human primary brain tumor, and its infiltrative nature represents the leading cause for the failure of therapies and tumor recurrences.
Cancer stem cells have also been detected in glioblastoma (GBM), the most malignant human brain tumor, with an annual incidence of 36 per million and a mean survival of less than 1 year [6] [8].
Eventually, this may lead to the most malignant human tumour (anaplastic thyroid carcinoma) with a life expectancy of only a few months.
In most malignant human tumours, the vasculature results from angiogenesis, as evidenced by the formation of a desmoplastic stroma containing small immature blood vessels clustered in vascular 'hot spots', and by a relatively high fraction of proliferating endothelial cells.
Glioblastoma multiforme (GBM) is the most malignant human intracerebral neoplasms, which display robust proliferation, resistance to detachment-induced cell death, diffused invasion into the adjacent brain parenchyma and result in escape of tumor cells to the standard polychemo and radiotherapies after surgical resection.
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GBM still remains one of the most malignant of human cancers, partly because of its refractoriness to current therapies.
GBM, the most malignant of human brain glial tumours, may develop de novo (primary GBM) or via another pathogenic pathway, that is, from a low-grade glioma (secondary GBM) and the molecular alterations leading to the development of GBMs may differ (Nakamura et al, 2000).
Plasmodium falciparum is the most malignant agent of human malaria.
Glioblastoma (Gb) (grade IV glioma) is the most malignant form of human brain tumour (Kleihues and Cavenee, 2000).
Glioblastoma multiforme (GBM) is the most malignant and invasive human brain tumor that is difficult to treat and has a very poor prognosis.
Glioblastoma multiforme (GBM) is the most malignant form of human astrocytoma [ 1] and the median survival of GBM has remained less than one year over the past decade.
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