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To date, the most major setback appears to have been when she and the sprinter Asha Philip locked themselves out of their hotel room at the holding camp in Barcelona, having to call the maintenance man to let them back in.
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"She has incredible strength and has developed an uncanny ability to persevere through the most major setbacks".
In addition, the pipeline would increase gasoline prices in America, add to our air pollution, and most importantly, be a major setback in the fight to reverse global warming".
Leaders of the Geffen Playhouse have spoken for years about building an endowment, but the most recent recession has been a major setback for those plans. .
WASHINGTON — The huge explosion that destroyed a major missile-testing site near Tehran three weeks ago was a major setback for Iran's most advanced long-range missile program, according to American and Israeli intelligence officials and missile technology experts.
In a major setback for President Álvaro Uribe, most of the 15 austerity measures that were voted on Saturday could be ruled invalid because the minimum 25percentt of the electorate did not vote.
"It's a major setback for them -- this was their most advanced product," Fariba F. Ghodsian, a health care analyst at Roth Capital Partners, said.
The most successful people in life display it after suffering a major setback.
A rejection tonight would be a major setback to the mayor and the chancellor, at a most difficult time.
The accident at Kamioka Neutrino Observatory, a large particle physics laboratory outside of Tokyo, is a major setback to research on the neutrino, one of nature's most elusive components.
What happened in Los Alamos has dealt a major setback, at least for now, to prescribed fire, the method most commonly used by federal officials to reduce fire risks on Forest Service and National Park Service lands.
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