We used the RCU platform to screen an array of 114 growth factors representing most major signaling pathways (Supplementary file 1A).
In particular, most major signaling pathways are present and vulval development has become a paradigm of organogenesis controlled by Ras/RTK and Wnt signaling; several components of these pathways were indeed first described in C. elegans [ 7].
Despite their complexity, there is a high degree of convergence throughout the animal kingdom in the basic molecular structure and targets of venom toxins, which include most major physiological pathways and tissues accessible by blood (Escoubas and King 2009; Casewell et al. 2013).
The transcriptomes were analyzed on an array of 1186 well-annotated cancer derived cDNAs containing most of the major pathways for malignancy.
Jahanshad et al. (2013a) screened a number of regions of interest across multiple cohorts, finding high heritability for most major white matter pathways and consistent heritability across pedigree-based and twin-based samples (Fig. 4; Kochunov et al. 2012; Jahanshad et al. 2013a).
Most major cellular processes and pathways were represented with no major predominance of any individual specific regulatory mechanism observed (Additional file 6: Table S3).
These genes contribute to the tumor signatures and in most instances, belong to major pathways that are dysfunctional in the tumor.
In agreement with this idea, we show here that most major players in three major PCD pathways and in particular proteins related to the p53-mediated apoptosis have relative high levels of intrinsic disorder and that there is a positive relationship between protein disorder and the number of interactions a protein has.
Thiamine biosynthesis (TBS) in most bacteria is accomplished by two major pathways; one involves the formation of hydroxymethylpyrimidine pyrophospate (HMP-PP) from aminoimidazole ribotide using ThiC and ThiD and the other involves the formation of hydroxyethylthiazole phosphate (HET-P) using ThiS, ThiF, ThiG, and ThiO.
In Synechocystis sp. PCC 6803 an L-arginine deiminase pathway and an L-arginine oxidase/dehydrogenase pathway represent the major pathways, while the L-arginine decarboxylase pathway most likely only functions in polyamine biosynthesis.
