This mouse model resembles most major features of the human syndrome, such as neonatal hyperbilirubinemia and early lethality due to bilirubin-induced neurological damage.
Liv-Ikk2ca mice and wild-type mice had similar expression of most major Cyps, (Additional file 3A).
Liv-Ikk2ca mice and wild-type mice had similar expression of most major UDP-glucuronosyltransferases (Ugts) and sulfotransferases (Sults) (Additional file 3B).
Liv-Ikk2ca mice and wild-type mice had similar expression of most major hepatic glutathione S-transferases (Gsts) [ 23], (Additional file 3C).
In an era when genomics tools are a mouse-click away and most major universities run dedicated core labs for proteomics, the scale and intensity of the six-facility Lipid MAPS approach may seem out of reach for nonspecialists.
Thus, IKK2 activation in adult mouse hepatocytes does not down-regulate most major DPGs.
Most major databases record interactions in different organisms such as human, mouse, yeast, fly and worm.
These mice demonstrate profound polyclonal lymphoproliferative disorders that infiltrate most major organ systems and die a few weeks after birth.
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