Most likely, the pathogenesis is multifactorial as it involves a combination of both viral and host-specific factors, including oxidative stress, hepatic steatosis, increased iron stores, and increased rate of hepatocyte apoptosis, under the pressure of the viral proteins and viral replication.
The resulting truncated TcdA lacking short parts of the CROP domain is cytopathic and most likely accounts for the pathogenesis observed in the variant C. difficile strains.
However, E. faecalis pathogenesis most likely involves an orchestrated interplay between the regulation of virulence factors and multiple genetic traits that govern adaptation of the bacterial cell physiology during the process of infection.
Mutations in 11 genes were detected of which the most likely candidates for AML pathogenesis were: DNMT3A, BCOR, YY2 and SSRP1.
Although this study has some limitations that may have prevented its detection, we believe that the iatrogenic dissemination theory remains one of the most likely explanations for the pathogenesis of nodal metastasis.
While endothelial damage is the most likely factor in the pathogenesis of pre-eclampsia, many factors associated with pre-eclampsia as well as their mechanisms are not well understood.
Because FASD is a developmental abnormality, disruptions in normal cellular differentiation driven by changes in gene expression that in turn are regulated by epigenetic mechanisms are most likely involved in FASD pathogenesis.
These processes, if deregulated, most likely contribute to a molecular pathogenesis of BEN and a predisposition to uroepithelial tumours.
Rothenberg and colleagues have reported that TSLP is the most likely candidate gene responsible for pathogenesis of eosinophilic esophagitis (24).
Compared to the HPS-like disease found in Syrian hamsters infected with ANDV, the onset of lung pathology can be detected in both models as early as 5-6 dafterfter challenge with an increase in severity peaking 10 12 days after challenge; the temporal differences in disease pathogenesis is most likely due to differences in challenge dose and route.
