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Most likely, novel potency assays needs to be developed and this requires innovation and basic research in combination with standardization and industrial quality systems and the pharma industry has a key role in these processes.
The prediction of [27], [28] is that those sequences falling on the scaling curve from genomic alignments are under strong evolutionary constraint; however, their functions – if not miRNAs - are most likely novel, presenting an intangible experimental challenge.
We further identified 20 genes as the most likely novel CHD candidate genes through gene prioritization analysis.
Functional analyses prioritized two genes at 20q11.22, EIF2S2 and GSS, as the most likely novel candidates responsible for the genetic association we observed in this region; both genes were significantly differentially expressed in the skin epidermis.
Most Ae. aegypti introns are shorter than 10,000 bp (average intron length 4,685 nucleotides [nt]) [ 16] providing strong support for the conclusion that we identified unassigned and un-annotated transcriptional units, most likely novel genes.
Many homologs of unknown sequences found in B. braunii 779 and Bot-88 suggest that these unknown sequences are most likely novel genes, part of which possibly encodes enzymes involved in VLCFA biosynthesis.
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Finally, we identified the most likely potential novel SNPs (Additional file 2: Table S13c), i.e. those that were present in the SAET-reads and the raw reads, and subjected these to Sanger sequencing.
Use of novel techniques including large‐scale genomics and proteomics in combination with relevant mouse models will most likely provide novel insights into the molecular mechanisms underlying glioma formation and will hopefully lead to development of treatment modalities for GBM.
When he discovers that Byron is also a writer, the old lion asks his wife's new pal for some help with his latest and most likely last novel, an epic of the Roman Empire that Byron recasts as a story of migrant farmworkers.
Thus, members of this group represent most likely a novel family.
We believed that these 167 sequences were most likely true novel miRNAs.
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