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Using genetics, the authors found that the target of LCA is most likely inhibited by Tor1 signaling and partially regulated by cAMP/PKA/Rim15, two pathways known to regulate aging rate in yeast [ 4, 5].
These results suggested that in Cln1 −/− mice, depolarization‐induced Ca2+ influx was suppressed, which most likely inhibited SV mobilization.
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Nonetheless, the enzymatic chemistry is similar, and serpins most likely inhibit both classes of enzyme in a similar fashion.
If that was the case, one would expect that impairment of myosin Va function should alter or, most likely, inhibit such mechanism.
Perhexiline, niclosamide, amiodarone and rottlerin most likely inhibit mTORC1 signaling by acting on upstream regulatory pathways, unlike the recently described inhibitors of mTORC1/2 Torin1 [61] and Ku-0063794 [62] and the dual PI3k/mTOR inhibitors PI-103 [63] and NVP-BEZ235 [64], which inhibit these kinases directly.
The low levels of the potent anaphyatoxin C5a observed in our study most likely inhibit the downstream terminal complement pathway.
Furthermore, aminoacyl-tRNA biosynthesis is down-regulated with 12 amino acids decreased and 6 genes down-regulated, thereby most likely inhibiting global protein synthesis.
1, 10-phenanthroline is a metal chelator that most likely inhibits transcription by sequestering divalent metal ions [37].
This suggests that PMX464 does not inhibit the IKK complex, directly, but most likely inhibits IKK activity at some upstream step.
As αv β5 integrin is upregulated in tumor blood vessels, ISM most likely inhibits tumor angiogenesis through this integrin in vivo.
The authors argued that genistein most likely inhibits PG synthesis through repression of transcriptional activation by growth factors (Swami et al. 2009).
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CEO of Professional Science Editing for Scientists @ prosciediting.com