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Pituitary tumors are the result of a monoclonal outgrowth where the intrinsic genetic defects involve oncogenes, tumor suppressor genes (TSG), and most likely genes responsible for differentiation.
To further refine this list of 703 copy number driven, differentially expressed probesets, we reasoned that those genes showing the strongest correlation of copy number and expression may be the most likely genes targeted by the CN gain.
Our combined association studies in human and pig in the predefined fatness related pig QTL region revealed three most likely genes, FAM73A, NEGR1 and TTLL7, as being responsible for genetic predisposition to common forms of obesity, especially subcutaneous fat thickness (Figure 5).
Although this hypothesis assumes identical rates of gene gain and loss, and our coarse calculations have not considered that new gene duplicates are also the most likely genes to be lost, the consistency of gene number among fully sequenced mammals suggests that this is not an onerous assumption across short evolutionary time periods.
We focused on matches to the 3'UTR of the target genes as the most likely genes regulated by miRNA.
* The approximate number of RefSeq genes for each CNV is given, but only the most likely genes for the phenotype are named.
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By retrieving the Rice Genome Annotation Project database (RGAP, http://rice.plantbiology.msu.edu), it was found that one of 25 candidate genes, Os06g10350, annotated as a MYB family transcription factor, was the most likely gene.
Several features are considered to identify the most likely gene pairs involved in a fusion.
The PrIME-DLRS gene-tree having best PrIME-PDLRS state with the highest posterior probability was selected as the most likely gene-tree.
Based on the biological function of these genes, SETD2 is the most likely gene to play a tumour suppressor role and explain our previous findings [ 2].
Based on the biological function of these genes, SETD2 is the most likely gene to play a tumour suppressor role and explain our previous findings.
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