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Future randomized control studies of rapamycin combined with chemotherapy in dogs with osteosarcoma can inform our understanding of how best to use rapalogs in microscopic disease, their most likely efficacious setting.
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4 Evidence suggests that complex, multifaceted interventions tailored to meet individual needs are most likely to be efficacious, 4 5 which is intuitive given the complex, multistage process that is taking medication.
If you pick a broad audience, there will be too much competition for you, and most likely, you would not be efficacious.
If the product is proven to be efficacious, exposure will most likely continue on a long term basis.
Finally, vaccines under development are only partially efficacious and will most likely require high coverage as a result.
An efficacious management would most likely stabilize or slow the cognitive decline; stabilize or prevent additional functional disability; and decrease the severity or delay the emergence of behavioral and psychological symptoms of dementia (BPSD) (See Table 3).
Here we develop mathematical models which reveal that the most efficacious treatments are not necessarily those most likely to spread.
Indeed, the human immune system itself can safely be assumed to be the best in generating highly efficacious antibodies and these antibodies are most likely superior to those generated from mice or using phage display.
Trastuzumab, most likely due to a multifaceted mechanism (for review, see Hynes and Lane, 2005) is efficacious against cancer that is driven by ERBB2 gene amplification (Slamon et al, 2001).
It hence appears that the regimen reported here is possibly as efficacious as the hypofractionated CRT schedules, albeit with the absence of significant toxicities, most likely reflecting the reduced fraction size.
Most likely.
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