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We conclude that NRG1 regulatory SNPs may confer an increased risk of HSCR by interfering with the normal NRG1 expression in human developing gut and their effect is likely to depend on the genetic background of the individual, most likely DNA alterations on trans-acting regulatory proteins expressed in the developing gut in a time-specific manner or in other main HSCR genes such as RET.
Most likely, DNA rearrangement occurred in this case.
Such data were used to draw the most likely DNA loop organization relative to the NM of the 162-kb region studied, by considering the distance (in kb) between the separate sequences mapped and the topological positions of such sequences relative to the NM.
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Most likely, DNA-binding of REV is affected by redox changes and also the transactivation activity or protein-protein interfaces, which will be further dissected in the future.
In this study, we observed that although AIRE is able to bind DNA-PK without DNA, most likely the DNA or chromatin is contributing to the AIRE and DNA-PK interaction (Fig. 2C).
As this high molecular weight band co-migrates with purified genomic DNA, it most likely represents DNA released from leukocytes which lysed during blood storage.
However, rather than DNA ends, in vivo DNA nucleosome remodeling will most likely encounter DNA-binding proteins such as TFs.
Such an approach will most likely involve DNA microchip technology and has the potential to overcome some of the limitations of pregnancy registries.
It is believed that the repetitive cycle of futile MMR results into a generation of tertiary lesions, most likely gapped DNA.
As it is not closely related to any domestic bird species (such as chicken or turkey), it most likely represents DNA endogenous to the analyzed feces rather than contamination from chemicals [24] or laboratory handling.
These regions most likely represent DNA that was acquired during events of HGT that may provide the strains with greater metabolic versatility or even virulence capabilities, as will be further discussed in the plasticity section.
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