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Although several potential hypoxic and nonhypoxic mechanisms have been associated with persistent hyperlactatemia [7 14], recent literature has highlighted the role of microcirculatory abnormalities [14] or hyperadrenergia [10, 11, 13] as the most likely determinants.
The most likely determinants are mutations in the nonstructural proteins encoding viral replication and protein cleavage mechanisms.
Mutations in the NS proteins encoding viral replication and protein cleavage mechanisms are the most likely determinants of differences in pathogenicity.
Although several potential hypoxic and nonhypoxic mechanisms have been associated with persistent hyperlactatemia [ 7- 14], recent literature has highlighted the role of microcirculatory abnormalities [ 14] or hyperadrenergia [ 10, 11, 13] as the most likely determinants.
This highlights residues lying between the beginning of TMD1 and the end of the cytosolic loop following TMD2 as the most likely determinants of IP3R1 targeting to the ER.
The molecular composition of A-type currents in myocytes of the systemic circulation is not clear at this time (9); however, Kv3.4 and Kv4 channels appear to be the most likely determinants of these currents in pulmonary arterial smooth muscle (20).
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Nonetheless, if adaptive advantage did in fact play a role, the most likely determinant of such an event is p120 itself, and both factors offer plausible advantages relevant to flexibility and/or function.
There are no agreed protocols for selecting patients whether ER negative or ER positive with other risk factors, yet control of breast cancer is the most likely determinant of survival where co-morbid disease is limited (Clarke, 2006).
This conclusion implicates the plasticity of the cancer-initiating cells as the most likely determinant of the tumor type, which may be different than the cancer-initiating cell phenotype.
A functional role of additional, most likely structural determinants of signal peptides is assumed [ 19].
The apparent affinity of activated GTPases for the tandem RBD region of RGS14 in vitro is weak (e.g., for H-Ras·GPPNHP, KD = 10 µM); it is thus most likely that other determinants and protein partners facilitate the formation of high affinity complexes in vivo.
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