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Local invasion by and dissemination of cancer cells from a primary tumor are key initial steps of metastasis, the most lethal aspect of cancer.
Beginning with the skin cells of patients with CF, Jayaraj Rajagopal and colleagues first created induced pluripotent stem (iPS) cells, and then used those cells to create human disease-specific functioning lung epithelium, the tissue that lines the airways and is the site of the most lethal aspect of CF, where the genes cause irreversible lung disease and inexorable respiratory failure.
Tumour invasion and metastasis remains the most lethal aspect of prostate cancer (Jaeger et al, 2001).
Our findings show that PKD1 inhibits breast tumour cell invasion and thus may influence tumour cell dissemination and metastasis, the most lethal aspect of breast cancer.
Tumour metastasis is the most lethal aspect of this disease, whereby tumour cells spread to local or often distant lymph nodes.
The establishment of a clinically relevant mouse model of TNBC is essential to identify and validate genes that might be involved in driving the metastatic cascade, the most lethal aspect of breast cancer, and for potentially screening novel drugs.
Similar(52)
The most lethal aspects of gastric adenocarcinoma (GA) are its invasive and metastatic properties.
The Chilcot report provides an utterly devastating indictment of Tony Blair's preparations for and conduct of the Iraq war, the most lethal and grotesque aspect of his legacy.
The most visible non-lethal aspect of what Israel is doing is treating wounded Syrians, both fighters and civilians, including women and children, who have been allowed to cross the Golan border – 1600 since February 2013.
But it is the most lethal.
Wastwater has the most lethal shore-path.
More suggestions(15)
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