Most of the large clusters are examples of functional information not exhausted by any operonal structure.
Patients with strains from most of the large clusters were present in the district throughout the study period.
We were able to show that most of the large clusters display a significantly higher expression rate which further correlates conserved gene position with essential biological functions.
Thus, clustering placed most genuine ORFs in large clusters as expected.
Sequences found most closely related to large clusters of Slovenian sequences were derived from USA, Germany, Belgium, Canada and France (data not shown).
Similar to the results obtained with fingerprinting, most isolates are in large clusters; 1,481 isolates are in the 20 largest clusters.
As shown in Fig. 4, the most significant focal points of large clusters of grey matter loss occurred bilaterally in medial temporal lobe (hippocampus/uncus; panels 2, 4), opercular cortex and insular cortex (panel 3).
After whole genome sequences for Leishmania and other trypanosomatids (i.e. T. brucei and T. cruzi) were completed, it was confirmed that in these organisms most genes are organized into large clusters on the same DNA strand.
In this study, the authors developed a measure for judging the quality of a clustering for homology detection by basically evaluating two aspects of the cluster-size distribution: (1) the number of genes in the core-genome (genes shared by all organisms) and (2) the number of unrealistically large clusters (which most likely contain false positives).
Most B-lymphoma cell lines, including RL, Raji, and BJAB, grow normally in large clusters, as do most of the B-lymphoblastoid cell lines.
