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PrimerBank contains primers for most known human and mouse genes (Table 1).
These reads were aligned to a database containing most known human genomes using Deconseq [ 22].
We previously reported the implementation of an algorithm to predict PCR primers for most known human and mouse genes.
Most known human intracellular mARTs resemble PARPs [ 26] and have until recently been classified as PARPs [ 24].
Most known human proteins have nucleic acid binding domains [ 32], so potential lncRNA protein interactions may act as adaptors to link lncRNA to target loci (Fig. 1a).
While many specific maturation steps have been uncovered for different miRNAs, most known human miRNAs are processed in the same way by the miRNA biogenesis pathway.
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The current circulating strains of influenza A/H5N1, with their human case-fatality rate of 30 to 80%, place this pathogen in the category of causing one of the most virulent known human infectious diseases.
Most importantly, known human leukemogens also produce leukemia (or some variant lymphohematopoietic malignancy) when administered to rats or mice.
It is the second most important known human carcinogen after tobacco [ 1, 2] and was estimated to have resulted in the deaths of 786,000 people in 2010 [ 3].
This accumulation of mobile DNA is apparently ongoing despite the fact that the most active known human transposable element, LINE 1 (L1), is relatively inactive compared to its counterpart in the mouse genome where ∼8% of spontaneous mutations arise through L1 retrotransposition [Ostertag and Kazazian, 2001].
The importance of ecological studies in causal inference concerning arsenic in drinking water was recognized by the International Agency for Research on Cancer (2004): For most other known human carcinogens, the major source of causal evidence arise from case control and cohort studies, with little, if any, evidence from ecological studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com