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The phrase 'most knowledge of' is correct and usable in written English
You can use it to express that someone is well-informed about a particular topic or area. For example, "John has the most knowledge of regional history of anyone in the department."
Exact(27)
Using the debate example previously mentioned (the pain-response of rats) a way to debate using the Socratic Method Most people assume that the person with the most knowledge of a topic will win in a debate.
Previously, most knowledge of mid-Miocene cooling came from marine records.
Most knowledge of postsynaptic neurotransmitter receptors comes from studies of the receptor on muscle cells.
At present, most knowledge of frictional heating in PEEK is based on post-hoc analysis of debris and wear surfaces.
Most knowledge of the effects of metals on benthic organisms comes from laboratory studies with subsequent extrapolation to field scenarios.
Despite these contributions, however, most knowledge of the brain and nervous functions came from studies in animals and from the microscopic analysis of nerve cells.
Similar(33)
Workers, not managers, would have the most intimate knowledge of these things.
He has taste, and, what is more, a most thorough knowledge of composition.
It will help them to understand the most sophisticated knowledge of their future job area.
Millions of others are missing even the most basic knowledge of what is possible.
Most current knowledge of cell biology comes from studying large populations of cells grown in petri dishes.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com