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Pancreatic adenocarcinoma (PAC) is one of the most intractable malignancies.
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Pancreatic ductal adenocarcinoma (PDAC) is one of the most intractable solid malignancies in humans.
Pancreatic cancer is one of the most intractable human malignancies, and the median survival of patients receiving the current standard therapeutic regimen with gemcitabine (GEM) is <6 months (Burris et al, 1997; Tempero et al, 2003).
Most of these tumors are characterized by diffuse infiltrative growth in the surrounding brain parenchyma which precludes curative treatment by surgery or radiotherapy alone, and together with their relative resistance towards conventional chemotherapy this places these tumors among the most intractable human malignancies [ 24].
But the most intractable problem of all remained the economy.
The conflict is one of Asia's most intractable.
Such problems are among the most intractable in mathematics.
You have solved one of maths' most intractable problems.
Heroin is among the most immediate — and the most intractable — social, economic, and political problems.
Knight promised to solve Tupac's most intractable problems.
And Mr Yushchenko should not be blamed for some of Ukraine's most intractable problems.
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CEO of Professional Science Editing for Scientists @ prosciediting.com