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In case of multiple metastases, the lesion with the most intense uptake were analyzed.
If more than one lesion were positive, the lesion which showed the most intense uptake was chosen as representative of all lesions.
If multiple metastases were present in the lymph node basin, the lesion with the most intense uptake was chosen.
Furthermore, we showed that there is no significant difference regarding the distribution of the most intense uptake among the different muscles of the FOM after a tracer uptake phase in the supine or sitting position (Table 3).
However, it is worth noting that considerable overlap in SUVs exists in indolent and aggressive NHL in many of the studies with the SUV being determined from the site with the most intense uptake rather than all sites of disease [ 36– 36].
For example, in triple vessel disease, in which tracer delivery to the whole myocardium is diminished due to balanced hypoperfusion, SPECT images may be interpreted as normal in qualitative or semiquantitative image analysis because comparison of the defective area with the region of the most intense uptake will not show any difference from normal.
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The analysis of distribution of the most intense FDG uptake among the different FOM muscles showed no significant differences between the patients examined after uptake in supine and sitting positions, respectively (Table 3).
For each PET data set, in patients with multiple lesions, the tumor with the most intense FDG uptake among all foci was identified by the maximal counts.
FDG uptake corresponded to abnormality on HRCT with the most intense areas of uptake corresponding most often to regions of honeycombing.
Grade 0: no tracer uptake by tumor; grade 1: tumor tracer uptake lower than the mediastinum; grade 2: equal to the mediastinum; grade 3: greater than the mediastinum; and grade 4: equal to the most intense normal tissue uptake.
Under normal physiologic conditions, neurons residing in the cortical gray matter, basal ganglia, cerebellum, and brain stem have the greatest glucose demand, resulting in the most intense F-FDG uptake [ 52, 53].
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