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However, contact among civilizations caused rapid spread and adaptation of most instruments in places far from their origin.
Most instruments in our study had a SD between 10-15% of the instruments' range, resulting in a required sample size of N = 400 to detect small differences between baseline and after four weeks [ 21].
A limitation of most instruments in the assessment of physical barriers is that they assess ability to access medications from vials only, whilst increasingly medications are supplied in foil or blister-packs which can also be difficult for patients to manage [ 1], and no instrument assesses ability to self-administer complex dose-forms such as inhalers and eye drops.
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These symptoms are associated with GERD syndromes but are not measured with most instruments used in untreated GERD.
Consequently most instruments used in clubfoot assessment are primarily for classification or cross sectional long-term outcome.
Due to the long tradition of depression research most instruments used in clinical trials are usually psychometrically sound.
Most instruments show limitations in diagnostic coverage.
Most instruments are developed in English.
Most instruments were tested in relatively small, homogenous samples recruited from a single setting.
In addition, for most instruments, the evidence of validity in severely injured children is still limited [ 27, 36].
In most instruments, this is accomplished with a monochromator.
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