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Analysis of the most informative parameters in CF and GA allows to better understand the complementarity of the two methods.
Indeed, whereas in GA the most informative parameters measure properties of individual residues, CF relies mostly on parameters relative to contacts at the interface.
Among the 10 most informative parameters in GA, 7 are relative to individual residues: volumes of R, E, K, P and I; and frequencies of K and 2. The surface of the interface appears in 4th position, and only 2 parameters are relative to contacts at the interface: frequency of Hydrophobic-Polar pairs and distances between Hydrophobic amino acids in contact.
Notably, RBC and PCV were the most informative parameters, representing valuable prognosticators in the routine clinical practice for anaplasmosis in sheep.
Taken together, the observed results stress the marked differentiation among the three breeds in terms of physio-pathological phenotypes indicating packed cell volume and red blood cell count as the most informative parameters in the routine clinical practice for A. ovis infection in sheep.
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Siegmund et al. found the average Hamming distance to be the most informative parameter of tumor diversity [3].
Tumour grade, as determined by the biopsy Gleason score (GS) is the most important predictor of outcome, and considered the most informative parameter for guiding management decisions.
In this model, continuously coded PCA3 represented the most informative parameter in the prediction of any PCa (AUC = 0.739) and HGPCa (AUC = 0.729).
Moreover, descriptive and semiquantitative analysis showed that the initial part of the curve is the most informative to distinguish benign from malignant tumors which suggests that tissue blood flow would be the most informative parameter.
One of the most informative motional parameters is S2, which describes the internal flexibility of a given amino acid in a protein.
The most informative new parameters derived from our current supercoil relaxation experiments with MCsp2 (1752 bp, 11.2 negative supercoils) are partitioning ratios ks→p/ ks→I1,2 and kI1,2→p/ klig (Table 2).
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