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FIR is one of the most informative analysis methods as it determines onset and full shape of the hemodynamic response function (HRF) without any a priori assumptions.
The KOG database delivered the most informative analysis, providing 10% more affiliation of transcripts to a category than GO and KEGG [ 45, 46].
Given the characteristics of a population, possibly derived from observed extant individuals, to estimate the (1) optimal sample size and (2) optimal sequence length for the most informative analysis.
Then, can such a generator be used to answer the "best-practice" questions about the population: what is the (1) optimal sample size and (2) optimal sequence length for the most informative analysis.
However, in our opinion, the analysis presented here is the most informative analysis that is possible at the current stage of development of this drug, as it not only takes into account the clinical results but also results from the preclinical phase.
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As the reviewers pointed out, the most informative comparative analysis concerned the dsrC AMG (detailed in response to question 3).
Furthermore, principal component analysis allowed us to identify a combination of 48 genes (Additional file 1), which proved to be the most informative during multidimensional analysis.
Therefore, by using the simplest, but most informative algorithm the analysis was more inclusive and directed towards the empirical evidence.
Data annotation and integration represents the final and most informative stage of analysis and requires computational and genomics background on genomic organization and structure (Step 16).
This approach supports the idea that there is not one single and most powerful or informative analysis, but a combination of them [ 33].
For the current analysis, we focused on biomarkers that were most informative in the previous analysis of first-year data (Delfino et al. 2008).
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