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Many of the well-known PTSD biomarkers such as FKBP5, STAT5A, HOXD3, VWA3, ALDH3B2, etc. were covered directly or as the secondary neighbors of the identified MRs. We were able to capture OAS2 as one of the most influential genes as the markers of the antiviral interferon response that was associated with an increased risk of PTSD50.
One of the most influential genes in this network wasSGK1, and it has a salt connection, helping cells manage sodium levels.
However, genes related to milk production, which were within the most influential genes of the mammary gland and have a high specificity of expression in this tissue (Table S13 and Table S14), showed an extreme drop in expression in the cancerous tissue.
The most influential genes appear as highly connected hubs.
Additionally, five of the most influential genes following 90 days of letrozole treatment are the targets of experimental compounds.
These most influential genes used in the classification process are identified in order to extract a feasible set of sex-specific genes.
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The most influential gene pinned down, KTN1, helps tell brain cells where to go in the putamen.
Gabra2, found down-regulated on all platforms and confirmed by qRT-PCR [see Additional file 2], is the most influential gene in these gene sets.
The second most influential gene (C3orf14) was up-regulated in high E2 but down-regulated among users of systemic E2 relative to non-users.
For all treatment conditions, the two most influential gene expression changes were those associated with uptake and phosphorylation of glucose (Enzyme Commission (EC) 2.7.1.1) and the decarboxylation of pyruvate to acetaldehyde (EC 4.1.1.1).
Brain pH was the most influential factor for gene expression with the median percentage of 1.28%.
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