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The gene that was most induced by both cytokines was MX1 which was increased 167.0- and 183.4-fold 183.4-foldand IL-29, respectively.
Intriguingly, the glycolytic transcript most induced by hypoxia in A. fumigatus was the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Afu5g01030, and this was verified with RT-PCR.
For each tissue, genes were ranked from most induced by smoking to most repressed by smoking using the signal-to-noise ratio for the effect of smoking.
Similarly, the sets of genes most induced by TGFβ from each of the seven datasets examined were enriched among genes whose expression decreased as a function of emphysema severity (FDR <0.05, GSEA).
Gene expression profiling of these cells demonstrated that the 200 genes most induced by GHK at 1 μM in cancer cell lines in the CMap dataset were enriched among genes that increased after treatment with GHK at 0.1 nM in fibroblast cultures (FDR <0.05, GSEA).
To further validate these findings, we cultured human lung fibroblasts with and without TGFβ1 and found that the set of genes most induced by TGFβ1 were enriched among genes that decrease in expression with increasing regional emphysema severity (FDR <0.05, GSEA; see Additional file 8 for the GSEA enrichment plot and Additional file 1 for the fibroblast culture methods).
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Table 3 The 10 most induced genes by treatment with 83 μA/cm2 DC.
Notably, the WRKY most strongly induced by YE (TC109669; almost 600-fold change) was induced five times higher than the most strongly MJ-induced WRKY (TC108267; 115-fold change) (Table 1).
The results suggest that pressure-induced muscle pain is mainly related to muscle strain and most efficiently induced by large rounded probes, while smaller and flat ones mainly activate superficial structures.
DNA is the cellular target that has the most damage induced by ionizing radiation (IR).
It is demonstrated that these traps are most probably induced by the extrinsic base implantation.
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