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The significant association between induced abortion and sexual intimate partner violence, in conjunction with most induced abortions undertaken in Tanzania being illegal and therefore likely to be unsafe, suggests that sexual intimate partner violence may have serious reproductive health implications for women beyond significant psychological distress.
Table 3 The 10 most induced genes by treatment with 83 μA/cm2 DC.
Most induced genes encode sensors or antiviral response determinants (ISG, IFIT, IRF, Mx).
Among these genes, the 17 most induced genes and the 17 most repressed were chosen.
In addition, we noted that 18 of the 25 most induced genes and 17 of the 20 most repressed genes during villous CTB differentiation are TFAP2A-dependent [25].
At each time point, the participant ranked the genes from most induced to most repressed compared to the wild type values at time zero.
The gene that was most induced by both cytokines was MX1 which was increased 167.0- and 183.4-fold 183.4-foldand IL-29, respectively.
Predictions for each time point were submitted as a ranked list with values from 1 to 50 sorted from most induced to most repressed compared to the wild type expression at time zero.
To gain insight into the molecular bases of the aforementioned transcription alterations induced by IVF followed by embryo culture, we analyzed the promoter composition of 34 genes corresponding to the 17 most induced and the 17 most repressed, using Principal Component Analysis (PCA) (for details, see Materials and Methods section).
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For example, the order of the top 20 most-induced pathways differed between the two conditions, with the "NF-κB-induced" pathway changing from being the most highly up-regulated in normal medium to the middle of the list in serum-free conditions.
The exact function of none of these ncRNAs is known, but we noticed previously that ncl1600 (NC-181) is the top most-induced ncRNA under iron limitation [ 15].
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