Indeed, it has been reported that miR159ab double mutant has pleiotropic morphological defects, including altered growth habit, curled leaves, and most importantly, small siliques and small seeds in Arabidopsis [ 51].
Most importantly, small sample sizes and the resulting decrease in statistical power owing to the difficulties associated with the identification and recruitment of SAID-discordant MZ twins with recent disease onset.
Our chosen species for this work was the zebrafish because its short generation time facilitates the life-long and multigenerational chemical exposures; it is a group-spawner (a common breeding system in fish); and, most importantly, small populations will spawn naturally in the laboratory without any manipulation.
Small ongoing improvements in assessments of all 5-year olds in school and, most importantly, a small but significant narrowing of the gap in results between the poorest children and their better-off peers have been seen.
Perhaps most importantly, these small cells emit less radiation, since they are not designed to provide as wide of coverage as traditional cell sites.
Most importantly, Jobs' small circle of trusted executives -- including Cook, Jonathan Ive, Apple's iconic designer, and Phil Schiller, Apple's marketing guru -- are less likely to leave now that Jobs is gone, said Tim Bajarin, president of the consulting firm Creative Strategies and a longtime Apple observer.
Most importantly, its small size and operational simplicity make the system suitable for single-user mode of operation, which is better suited to electrophysiological inquiry than the currently prevailing "imaging facility" mode.
Most importantly, synchrotron small-angle X-ray scattering (SAXS) data indicate the presence of a 1∶1 complex, which, in ab initio modelling, shows a highly similar conformation to the canonical collapsed mode of CaM-peptide interaction, seen also for peptides from CaMKs.
Most importantly, the small cohort size limits conclusions regarding 3-month outcomes.
There are some limitations to the current study, most importantly the small number of patients (n = 13) who were included.
