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In addition to pressure changes, alterations of alveolo-capillary barrier permeability are involved in the development of pulmonary edema during high-volume ventilation of intact animals and are the most important responsible for VILI.
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Guclu et al. [ 47] observed a significant decrease in serum IL-12 (one of the most important cytokines responsible for Th1-type cytokine responses), a statistically non-significant decrease in IFN-γ and no change in serum IL-2 or IL-4 in patients with hypothyroidism due to Hashimoto's thyroiditis who underwent 12 weeks of LRT.
According to several authors, DCs are one of the most important cells responsible for activating an efficient immune response, and these cells have been used as tumor treatments in immunotherapy models [39], [40].
Interestingly, our results demonstrated that downregulation of CXCR4 is responsible for the "loss of adhesion," one of the most important events responsible for the cancer cell metastases.
Tysabri was by far its most important product, responsible for almost all of its revenue.
Automatic control represents one of the most important factors responsible for the efficiency and reliability of wind power conversion systems.
Unplanned slope cutting for the construction of road is the most important factor responsible for landslide and soil erosion.
One of the most important interactions responsible for protein folding and stability are hydrogen bonds between peptide groups.
The dark-current reduction is one of the most important factors responsible for a large S/N.
Flavor is one of the most important components responsible for the overall sensory properties of taste and smell in any food products (e.g., soft drinks).
Pesticide-induced tissue destruction and hepatocyte apoptosis might be the most important agent responsible of reducing the synthesis of total protein in the liver (Gokcimen et al., 2007).
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CEO of Professional Science Editing for Scientists @ prosciediting.com