Sentence examples for most important mutations from inspiring English sources
L858R, T790M and E746-A750 are known as the most important mutations which are directly related to drug responses [1].
Nevertheless, "they capture most if not all of the most important mutations," says Eduard Batlle at the Institute for Research in Biomedicine in Barcelona, Spain.
In the present study, a low-cost low-density DNA array including four genetic regions (rrs 530 loop, rrs 1400, rpsL and gyrA) was designed for the rapid detection of the most important mutations related to anti-TB injectable drugs (mainly streptomycin) and fluoroquinolone resistance (LD-SQ array).
All of the most important mutations of this population are represented in Table 3.
To identify the most important mutations for species specificity, we reduced the number of mutations introduced into FLCE in a stepwise manner.
One isolate was found with the G145R mutation, which is one of the most important mutations in the HBV S region [ 19].
E138K is the most important mutation associated with resistance against rilpivirine and its development must be avoided whenever possible, because this mutation confers broad cross-resistance against all approved members of the non-nucleoside reverse transcriptase inhibitor family of drugs.
HRM does not require post-PCR separation, significant cost savings are achieved and becomes the most important mutation detection technique and has been widely applied in the polymorphisms detection and epigenetics studies [ 22, 37, 38].
After optimizing the operation parameters, we verified the new strategy with cell mimics, which contain three most important EGFR mutations.
BRCA1 (breast cancer 1) genomic deletions are the most important founder mutations in breast cancer patients and can be passed to you from your mother or father.
Of the known causative factors for the development of core myopathy, genetic factors seem to be most important, as mutations in the skeletal muscle RYR1 gene and less frequently in the SEPN1 gene contribute to disease development.
