Sentence examples for most important mediator from inspiring English sources

He and the Beatles were mutual fans - he once referred to John Lennon as "the most important mediator between popular and serious music" of the 20th century.

And in Mr. Kurtz's book (and the script of "1969") Stockhausen is quoted calling Lennon "the most important mediator between popular and serious music in this century".

Research confirms that the most important mediator of immunity to EPM is interferon-gamma, while the humoral immune system also contributes via inactivation of specific protozoal surface proteins.

PKB is the most important mediator of the PI3K signaling and, from our data, PKBα is the main functional PKB isoform positioned downstream of PDK1 in thymocytes.

Nicotine is thus not the sole or even most important mediator of tobacco's harmful effects, and studies demonstrating its angiogenic and proliferative properties through nAChRs on endothelial cells have hinted at the intriguing and varied bio-activities of this compound.

Among these transporters, the ABCB1 transporter is the most important mediator of MDR [7], [8], and is responsible for chemotherapeutic drug resistance to a variety of drug, including vinca alkaloids, anthracyclines, epipodophyllotoxins and taxanes [9].

Most important mediators in the EAR are preformed mediators, newly synthesized lipid mediators and cytokines that are produced by mast cells.

In this review, the most important mediators involved in the induction phase, the early-phase and late-phase asthmatic reaction are discussed.

Interleukin-6 (IL-6), an inflammatory cytokine, is one of the most important mediators of fever, the acute phase response, and inflammatory conditions.

Current evidence points to members of two families of metalloproteases, the MMP (matrix metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) families, as being the most important mediators of aggrecan degradation (Sztrolovics et al.[1997]).[1997]

Cytotoxicity is the main mechanism by which CD8+ T-cells exert their antiviral activity with perforin as one of the most important mediators of T-cell cytotoxicity [15].