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Identification of the most important endpoints: This was carried out not by the QSAR modellers, but by the stakeholders.
The way in which the directive inspired the work can be summarised as follows: Identification of the most important endpoints: This was carried out not by the QSAR modellers, but by the stakeholders.
In the sense of the presented test strategy, most important endpoints to be considered include further (a) biotic transformation/degradation, mobility and transport in porous media, and sorption to soil, sediment and sludge of the pristine and aged ENM.
However, the available studies are limited by an inadequate consideration of some of the most important endpoints in chronic headache research, namely the frequency of headache and the consumption of medications for acute headaches management.
The two most important endpoints driving Cat 2 classification are conjunctiva redness (75 81 %) and corneal opacity (54 75 %).
In examining the nephrotoxic effects of xenobiotics, one of the most important endpoints that investigators must evaluate is cell death.
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Among the endpoints of the studies based on which efficacy is measured, OS is recognized as the most important endpoint [9].
The last, and possibly the most important endpoint in toxicology, which has been investigated in screening strategies, is the toxic effects on development.
Reduced sulphur species represented the most important endpoint for these NPs in the sewer with slight differences in terms of speciation; ZnO converted largely to Zn sulfide, while Ag was also sorbed to cysteine and histidine.
The most important endpoint for treatment efficacy, since there is not an externally measurable lesion, is survival of mice bearing the human lymphoma cell lines.
Although bodyweight is the most important endpoint of any cachexia treatment, body composition, physical performance and quality of life should be monitored.
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