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Reduced sulphur species represented the most important endpoint for these NPs in the sewer with slight differences in terms of speciation; ZnO converted largely to Zn sulfide, while Ag was also sorbed to cysteine and histidine.
The most important endpoint for treatment efficacy, since there is not an externally measurable lesion, is survival of mice bearing the human lymphoma cell lines.
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The most important endpoints for safety were injection site and general symptoms that we solicited from subjects by asking them to maintain a diary for 21 days after each vaccination.
The most important endpoint of this study was to define whether CNB is an appropriate strategy for the diagnosis of lymphoma arising in a patient population from a primary care institution.
"If F.D.A. sets a precedent of approving a drug based on progression-free survival, people are afraid they may stop looking at survival as the most important endpoint," said Dr. Kay Dickersin, director of the Center for Clinical Trials at Johns Hopkins University.
Among the endpoints of the studies based on which efficacy is measured, OS is recognized as the most important endpoint [9].
The last, and possibly the most important endpoint in toxicology, which has been investigated in screening strategies, is the toxic effects on development.
Identification of the most important endpoints: This was carried out not by the QSAR modellers, but by the stakeholders.
However, the available studies are limited by an inadequate consideration of some of the most important endpoints in chronic headache research, namely the frequency of headache and the consumption of medications for acute headaches management.
There is no single best statistical procedure for multiplicity adjustment because the choice of procedure depends upon the study objectives, the most important endpoints among the collection, and other considerations.
The two most important endpoints driving Cat 2 classification are conjunctiva redness (75 81 %) and corneal opacity (54 75 %).
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