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One of the most important drawbacks of this type of algorithms is that the number of weights strongly depends on the dimensionality of the problem which is often unknown in practice.
The microstructure obtained is a new bio-inspired/bio-mimetic approach to solving one of the most important drawbacks of titanium implants, i.e., bone resorption due to the stress-shielding phenomenon.
The high synthesis cost, the poor hydrothermal stability of the pore structure and the extensive leaching of the active metal sites in liquid phase heterogeneous catalysis are three of the most important drawbacks for the industrial use of the newly developed mesoporous crystalline materials (MCM-41, MCM-48, HMS, FSM, …).
One of the most important drawbacks of LEZs is the citizens' risk to be tracked by means of their interactions with the Electronic Road Pricing ERPP) system in use; another relevant problem is the significant error percentage on the detection of fraudulent drivers.
One of the most important drawbacks in applying whole-body MDCT is the high-radiation dose in access of 35 mSv [ 10].
One of the most important drawbacks of such studies is that subjects may be lost to follow-up at any time point.
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The most important drawback of these methods is their invasive nature and radiation exposure [34].
The most important drawback that limits the use of PbS nanoparticles in many applications is their low chemical stability.
However, the most important drawback for practical applications is their complication, and chromatographic techniques do not lend themselves to rapid analysis or to on-site studies.
The most important drawback of selecting low quality nitrates salts for high temperature CSP applications is the corrosion impact produced by impurities.
The most important drawback of MA-XRF scanning is the fact that the technique is not depth selective, with elemental images that can show contributions from different levels in the stratigraphy [6].
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