The most important aspect of this damage is disruption of the endothelial glycocalyx through actions of mediators dysregulated by the diabetic milieu.
Protecting patients from injuries such as falls and preventing treatment disruption are the most important reasons given for the use of physical restraints by all professional groups [ 2, 3].
The remarkable levels of price stability for crude oil along the world's most important benchmarks, in the face of large disruptions in supply from some of the Middle East's key suppliers, have left many observers somewhat stunned.
Employment remains the most important problem to people around the world, yet disruption is increasingly replacing jobs with automation.
In particular, out-of-pocket expenses and the risk reduction to disruption of chemotherapy schedule were most important to those surveyed patients.
The ability to confidently confirm or negate a diagnosis allows control efforts to focus on the most important cases and minimizes unnecessary social and economic disruption.
Because endotracheal intubation is the most important predisposing factor for ventilator associated pneumonia, bronchial stump disruption and bronchopleural fistula, postoperative re-intubation must be avoided.
We hypothesize that Sec8's most important role in vivo is spatially-restricted inhibition of microtubule stability, and that disruption of microtubule regulation may underlie most, if not all, sec8 mutant phenotypes.
The most important and critical adverse effects of anaesthetic agents are depression of respiration, cardiovascular system disruption and thermoregulation.
The most important causes of disc degeneration may be the various processes that weaken a disc before disruption or that impair its healing response.
