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Ecozone variability was the most important confounding factor in the evaluation of the long-term effects of OM removal on soil genetic potential.
Moreover, most of them were characterized by a marked increase in bone marrow fibrosis, ranging from MF-2 to MF-3, which probably represents the most important confounding factor.
The definition of AE is the most important confounding factor.
Because at least 10 episodes of extubation failure were required in order to conduct multiple regression analysis adjusted for APACHE II score the most important confounding factor for extubation outcomes the estimated minimum sample size needed for the statistical analysis was 135 with a predicted extubation failure rate of 8%, as indicated by the past extubation failure rate in this ICU [18].
Maternal asthma was the most important confounding factor in the adjusted analysis, followed by birth weight.
It is known that besides speed, inter-trial variability is the most important confounding factor [ 35].
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We considered age, sex, and smoking as the most important confounders in this study, although residual confounding remained.
Nevertheless, we were able to control for the most important potential confounding factors and still the difference in CHD incidence between the COMT activity categories among heavy coffee drinkers persisted.
The most important missing confounding factors are surgery in more complicated cases, high BMI, alcohol abuse and smoking, number of other institutional care facilities in the hospital district, the distance between other care facilities and the hospital, the annual arthroplasty volume of surgeons, and the socioeconomic status of patients.
Confounding by indication is possibly the most important type of confounding that threatens the validity of pharmacoepidemiologic studies.
The most important was the confounding by current use of HT, which could be a serious bias in ecological analyses due to its known carcinogenic properties [ 30].
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