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We considered age, sex, and smoking as the most important confounders in this study, although residual confounding remained.
Although we were able to adjust the differences in outcome between the two patient groups for the most important confounders, we cannot exclude some residual confounding by unmeasured factors.
In the model that was formulated, the most important confounders were dealt with, but the existence of other confounding factors cannot be excluded.
Nonetheless, accounting for the most important confounders is essential for any genetic study, for not doing so would lead to type I errors (false positives, where false genetic loci show up as significant) and type II errors (false negatives, where real genetic loci are covered by noise).
The most important confounders are SES, parental IQ, and the quality of the home environment.
We did, however, account for two of the potentially most important confounders: maternal and gestational age.
Similar(36)
Because the same variable maternal education was used to apply weighted outcome misclassification corrections, and serves as the most important confounder, simultaneous consideration of confounding and outcome misclassification was not possible, and is a limitation of this approach.
Age could be the most important confounder in this study, because age has a very strong relationship with both actinic skin damage and all-cause mortality.
Child abuse was the most important confounder in the models.
However, we believe subject age to be the most important confounder in this experimental setting.
Again, chronic kidney disease was the most important confounder in the adjusted model.
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