Sentence examples for most important alteration from inspiring English sources

In conclusion, we suggest that the [Ca2+]i, Cal-1 and -2, Csp -12 and Csp-3 cascade in involved in the CF physiopathology because this cascade is altered in CF cells and that the most important alteration concerns Csp-3.

A recent study reveals that PTEN loss activity is the most important alteration for cellular malignant transformation in mammary epithelial cells [ 102].

As a single event, losing PTEN was the most important alteration in mammary epithelial cells as it was the only alteration to cause them to grow in the absence of mitogenic stimuli.

Protein synthesis is rapidly increased in skeletal muscles after oral feeding due to intracellular signaling for activation of initiation or protein translation [ 1], which is quantitatively the most important alteration in the control of short term protein balance in skeletal muscles [ 2, 3].

A further restriction of the B-cell compartment in DS was observed at the memory stage with the number of IgM memory B cells being 30% of those seen in the CTR children; however, the most important alteration was observed in the switched memory pool.

Vascular stiffening is considered one of the most important alterations to aged vessels.

The most important alterations observed in alcoholic liver disease are desialylation of transferrin and also haptoglobin, alpha 1-antitrypsin, and ceruloplasmin [ 6, 18].

The most important anthropogenic alteration of the natural environment was the clearing of forests to establish cropland and pasture, and the exploitation of forests for fuel wood and construction materials.

By far, his most important constitutional alteration was his creation of a bureaucratic apparatus, which included a fixed gradation of clearly defined offices, and a corresponding order of promotion.

This is the most important pharmacokinetic alteration in the elderly.

The choroid is the site of the most important vascular alteration associated with SWS.