Several human diaphorases are known (Jaiswal et al, 1990 , 1991 Riley and Workman, 1992), but NQO1 is most important for activating bioreductive agents (Jaiswal, 1991; Riley and Workman, 1992; Belinsky and Jaiswal, 1993).
One of the most important mechanisms activating endothelial cells during sepsis is the endothelium-specific angiopoietin (Ang) tyrosine kinase with the immunoglobulin-like loop epidermal growth factor domain (Tie) ligand receptor system, which has a potential correlation with endothelial injury severity.
The present study as well as recent reports (Isshi et al, 2002; Fujii et al, 2003) disclosed that the OPRT pathway was the most important to activate 5-FU among the three pathways.
'DNA Replication, Recombination and Repair' represented one of the most important mechanisms activated in non-responsive cervical tumors, and the 'Role of BRCA1 in DNA Damage Response' was predicted to be the most significantly altered canonical pathway involved in intrinsic resistance (p = 1.86E-04, ratio = 0.262).
Among the most important kinases directly activating eNOS by phosphorylation are Akt and AMP-activated protein kinase (AMPK) [15].
Although the dephosphorylation of Site-1 and Site-2 plays the most important role in activating KCC isoforms [ 42], recent work has shown that dephosphorylation of Site-4 is also required for maximal KCC3A activation [ 51].
The most important adsorbents are activated carbon, prepared by partial volatilization or combustion of a carbonaceous body, and activated alumina, silica gel, and molecular sieves which are all formed by expulsion of water vapor from a solid.
Moreover, the recognition between IFN- λ and its receptor is the first and most important step to activate the host's antiviral immune response.
As expected, glucose concentration positively correlated with the flux of lactate formation through EM 11, and serine concentration is the most important factor that activates glycine production through EM 6.
IFN-gamma are essential for the development of protective immunity against TB [ 33, 34] and is probably the most important factor that activates macrophages antimycobacterial action, at least in TB response [ 19, 35].
