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The phrase 'most impactful' is correct and usable in written English.
It can be used to describe something that has the greatest amount of influence or effect. For example: "The most impactful message of the speech was the importance of taking action against climate change."
Exact(59)
It's the most impactful game in of all of sports".
You have to, or you will not be the most impactful member of this team.
A third way, arguably the most impactful change, may prove simply too expensive for traditional donors.
"The most impactful moment for me was walking through the door," he said.
"I think that our emoluments case is going to be the most impactful of all".
"Mark is the most impactful person of his generation," he told me.
He is truly one of the most impactful people that I've met.
What was probably the most impactful to me came from Bob Probert's book.
And for that younger audience we're delivering this incredible music in the most impactful way imaginable.
I am the number one most impactful artist of our generation.
"I remember at U-11 thinking that she's the most impactful player I've ever coached," he said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com