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While most identified genes show a strict monoallelic expression in all cDNA samples tested (from 8 to 11 independent samples), two genes have a less stringent profile.
Most identified genes required for increased CTBT susceptibility were found to be involved in mitochondrial biogenesis and function, DNA repair, gene expression, lipid metabolism and stress response (Table 1).
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This showed that most identified gene products clustered in several categories, all relating to "immune response".
The 100 most frequently identified genes were taken as the enriched subset.
CASC5 is among the most recently identified genes responsible for MCPH [ 72].
The most commonly identified genes in these groups encoded restriction-modification systems or hypothetical proteins (Table 5 and Additional files 4, 6, 7).
Likewise, after analysis of overlaps larger than 60 bp among 338 prokaryotic genomes, it was found that the annotation of most previously identified genes was incorrect [ 6].
Although most of the identified genes (44%) encoded mobile elements related to transfer functions, 12% encoded mercurial-resistance determinants, 16% encoded metabolism-related genes, and 28% encoded hypothetical proteins (HPs).
Most of the identified genes relate to the immune system, particularly the major histocompatibility complex (MHC) and T cells.
Most of the identified genes belong to H-L-L H-L-L H-L-Lxpression clusters.
Most importantly, we identified genes and pathways that might be involved in locust development and phase change, and may thus benefit pest management.
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CEO of Professional Science Editing for Scientists @ prosciediting.com