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Most hypothalamic brain regions contained CCKAR-immunoreactive nerve fibers.
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However, our findings indicated a lack of GSK3β staining in most hypothalamic areas of the adult mouse brain, whereas previously strong labeling of GSK3β was noted in this region of the brain in the adult rat [28].
In this report, we provide evidence that IL-7 targets hypothalamic brain areas to regulate body weight and feeding behavior.
Serial coronal hypothalamic brain slices (25 µm) were collected using a cryostat and stored at −80°C until hybridization.
These findings suggest that the BBB develops at different rates in the CTX compared to the hypothalamic brain regions examined.
Most hypothalamic nuclei are not identified and their absence has been correlated with some clinical hallmarks of the disease [ 118].
More recently genetic reporter systems have identified the brain regions that express ObRb, and in accordance with previous in situ hybridisation and immunocytochemical studies high levels of expression of ObRb were detected in hypothalamic and extra-hypothalamic brain regions [ 12].
However, Ob-Rs are also highly expressed in many extra-hypothalamic brain regions including the amygdala, cerebellum, hippocampus, brain stem and substantia nigra [ 11].
However, leptin receptors are also widely expressed in many extra-hypothalamic brain regions including the cortex, hippocampus, brain stem and cerebellum.
Hypothalamic deep brain stimulation.
ONS is relatively safe compared to other invasive techniques, chiefly hypothalamic deep brain stimulation.
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