Sentence examples for most human tumours from inspiring English sources

The p53 pathway is aberrant in most human tumours with over 50% expressing mutant p53 proteins.

In most human tumours, the stroma microenvironment is heavily altered compared with the stroma of normal tissue [ 1].

Evasion of programmed cell death (apoptosis) is a phenotypic hallmark that is shared by most human tumours (Hanahan and Weinberg, 2000).

In this context, most human tumours are characterised by an imbalance of regulatory mechanisms controlling cell cycle progression, cell death/viability balance, and apoptosis.

Vascular endothelial growth factor is now known to be a key regulator in neoplastic angiogenesis and its expression is upregulated in most human tumours (Ferrara and Davis-Smyth, 1997).

The loss of RB1 is also a well-characterised occurrence in many other human tumour types and it is probable that the p16INK4a-CDK4/6-RB pathway is disrupted in most human tumours [ 2].

However, most human tumour samples for which long term clinical records are available exist only as formalin-fixed paraffin-embedded specimens.

It is also detected in most human tumour samples analysed (Counter et al, 1994; Kim et al, 1994) suggesting that telomerase activation may represent an essential step in tumour progression.

Screening for chemicals or downregulated genes synthetic lethal with VHL inactivation was made possible by the observation by Kaelin's group that unlike most human tumour suppressor genes ectopic expression of VHL does not lead to inhibition of cell growth or of cell-cycle distribution in vitro, but rather to suppressing tumour formation in nude mice xenografts (Iliopoulos et al, 1995).

The fact that most human tumour cells have telomerase activity indicates that its acquisition is vital for carcinogenesis and cell immortalization, and it might explain the reason why lung adenocarcinomas with or without ALK fusion shows similar frequency of copy number gain of this locus.

Histological studies have shown that most human breast tumours appear to be derived from TDLUs and have morphological characteristics of luminal epithelial cells (reviewed in [ 2]).