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Increasing evidence has demonstrated that miRNA dysregulation could lead to a large number of genetic diseases and miRNA expressions are closely associated with the pathogenesis of most human malignancies.
Compared with their somatic counterparts, most human malignancies demonstrate telomerase activity, and this activity is dependent on the cellular presence of hTERT.
Age is the strongest demographic risk factor for most human malignancies, including breast cancer [ 1].
These novel data may have clinical relevance, since most human malignancies exhibit aberrations in cell cycle regulation [ 22].
Chromosomal abnormalities have been associated with most human malignancies, with gains and losses on some genomic regions associated with particular entities.
TFF3 is upregulated in most human malignancies, and the protein's expression is correlated with a highly aggressive phenotype and poor prognosis [ 15, 25, 26].
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Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is one of the most formidable human malignancies, with the annual mortality nearly equaling the annual incidence.
Pancreatic adenocarcinoma, the most common form of cancer in exocrine pancreas, is among the most lethal human malignancies (Siegel et al., 2011).
Glioblastoma multiforme (GBM) is the most common malignant tumour occurring in the central nervous system, and one of the most devastating human malignancies.
Distinct from most other human malignancies, metastases at distant sites are often confined to late stages of ovarian cancer, and the most serious problem for HGSC patients is recurrent and aggressive growth of metastatic lesions within the peritoneal cavity (Pogge von Strandmann et al., 2017).
However, like most human solid malignancies, ovarian cancer has distinct environmental landscapes and display substantial heterogeneity, even standardized treatments elicit a varying degree of responses among patient subgroups.
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