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TP53 mutants (mutp53) are involved in the pathogenesis of most human cancers.
Furthermore, there is the ever-present anxiety that telomerase reactivation is a hallmark of most human cancers".
"This novel insight indicates that most human cancers may be eligible for successful cancer immunotherapy.
Loss of p53 suppressor function, through mutations or inactivation of the p53 pathway, occurs in most human cancers.
Most human cancers lose p53 function, yet all three proteins are capable of inducing apoptosis or cellular senescence.
Although viruses play no role in most human cancers, a number of them do stimulate the growth of tumours in animals.
Professor Lu's research team has been one of the major research groups in the world to study the regulation of the tumour suppressor function of the p53 protein whose function is lost in most human cancers.
And, at the same time, some epidemiologists have gleaned increasing evidence that most human cancers are caused not by synthetic chemicals in the environment but by natural substances that make cells divide.
Like the supernumerary chromosomes that vary from cell to cell in individuals with MVA, most human cancers are aneuploid, and chromosomal instability presumably drives tumor progression by accelerating the rate of gain or loss of individual chromosomes.
BACKGROUND: Most human cancers are thought to arise from alterations in oncogenes and tumor suppressor genes.
Interestingly enough, the human homolog of this very molecule is known to play a quite important role in most human cancers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com