The third putative reductase, NPH_5472-NPH_5476, is one of the most highly upregulated clusters during naphthalene degradation, but shows little or no upregulation during benzoate metabolism.
MtSERK4 and MtSERK6 are the most highly upregulated SERKs in culture with both showing greater than 12 fold upregulation of expression in the first week of culture.
The pattern of most highly upregulated genes by S100A8 and S100A9 (10-7M) were similar with, from most to least upregulated, Mmp13 then Mmp1 then Adamts4 then Mmp3 and finally Adamts5.
Candidate sequences were extracted from the 50 most highly upregulated genes from the microarray analyses.
Among the genes with FPKM > 0, |log2Ratio| ≥ 1 and q-value | FDR ≤ 0.05, MYOD was the most highly upregulated gene in either fusion protein transfected cells (Fig. S3), indicating that the dCpf1 approach was robust and specific.
Therefore, Serpin-a3n ranks among the most highly upregulated transcripts in prion-infected brains.
LILRB2, the most highly upregulated inhibitory ILT in our study, is also upregulated in HIV patients and may impair the antigen presentation of monocytes [43].
Indeed, the most highly upregulated gene of the entire set is per2 (induced 30 fold in larvae after 3 h and 23 fold in cells).
By combining these five studies, Endo180 was ranked as the 6th most highly upregulated gene in GBMs versus grade III gliomas (p = 5.56×10−5) (Table S2).
Further, interrogation of multiple expression array datasets identified Endo180 as one of the most highly upregulated transcripts in grade IV GBMs compared to grade III gliomas.
For visualization of global microRNA::mRNA interactions in ULMs, box plots were used as a convenient way of graphically depicting the regulation of the mRNA targets of the 5 most highly upregulated and 5 most downregulated microRNA.
