Table 4 and Table 5 showed the 36 most highly repressed and induced genes, many with known roles in oxidative stress response, including catalase, oxidoreductase, N-acetyltransferase.
On the other hand, the genes encoding the cytochrome P450s CYP71A12, CYP82C4 and CYP81F2 were among the 10% most highly repressed genes in glu1-2 roots.
This reduced precision is because the down-regulated pathway found by ambient is very large, reflecting the general downshift in metabolism rather than just the most highly repressed enzymes.
Down-regulated genes (Fig. 2) mostly belong to the functional class termed "Energy Metabolism"; 42 of the 118 repressed genes (35%) belong to this group, and they are amongst the most highly repressed.
Among the most highly repressed genes upon PPARα activation were several chemokines (e.g. CXCL9-11, CX3CL1CXCL61, CXCL6), interferon γ-induced genes (e.g. IFITM1, IFIT1, IFIT2, IFIT3) and numerous other immune-related genes (e.g. TLR3, NOS2, and LCN2).
For example, Lsp1beta and Lsp2, which encode amino acid reservoirs [ 26, 31], are among the most highly repressed genes at 24 and 48 hours post-mating, but not at the 0-2 hour post-mating stage.
DCBLD2/ESDN/CLCP1 (discoidin, CUB and LCCL domain containing 2/Endothelial and Smooth muscle cell Derived Neuropin-like molecule/CUB, LCCL-homology, coagulation factor V/VIII homology domains protein) turned out to be the most highly modulated (repressed) gene in our microarray analysis on HeLa cells (FC + 5.7) and to have an important role in cell migration [ 39].
On the other hand, UpA dinucleotides are highly repressed in DNA sequences of most organisms [7], [31], [45], [46].
Most of the genes important for sporophytic organs are highly repressed in pollen.
Unexpectedly, we found that inactivation of Rfx6 in adult β cells caused the re-expression of the "disallowed" genes (Pullen et al., 2010; Quintens et al., 2008; Thorrez et al., 2011), a set of genes expressed normally in most (if not all) mammalian tissue but selectively and highly repressed in mouse mature β cells.
The most important one is a NAM transcription factor gene (Oso4g38720) in the Rhz3 interval, which was highly repressed in RT relative to ST.
