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Our results were verified using a Taqman-based genotyping assay that detects both of the most highly recurrent TERT promoter mutations (C228T and C250T).
The most highly recurrent aberrations revealed in this study are evolutionarily conserved with those reported in human histiocytic proliferations, suggesting that human and dog HS share a conserved pathogenesis.
The most highly recurrent canine CNAs revealed in this study are evolutionarily conserved with those reported in human histiocytic proliferations, suggesting that human and dog HS share a conserved pathogenesis.
Among the most highly recurrent CNAs detected were loss of regions of CFA 2, CFA 11, CFA 16, CFA 22 and CFA 31, all of which were highly frequent 50-866%) in both breeds.
The most highly recurrent triple-negative BC-specific amplicons in BC cell lines were on 5p15.33-p15.1 (HCC1143, HCC1937, HCC1954, HCC70, MDAMB468 and BT20), followed by 9p24.3-22.3 and 7q11.1 found in 6 "Cluster 3" cell lines and 4 "Cluster 3" cell lines, respectively.
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It is a common disorder, and for most sufferers, is highly recurrent and associated with significant psychosocial impairment as well as a high rate of completed suicide (Fajutrao et al. 2009).
Analysis of the effect of de novo 1q gain on gene expression in recurrent ependymoma revealed that CHI3L1 was the most highly expressed gene.
In contrast with these highly recurrent mutations, a recent study of 112 aggressive primary prostate cancers has reported that the most significantly mutated gene (SPOP) was altered in only 13% of cases, with the next most commonly affected gene TP53 affected in only 6% of prostate tumours (Barbieri et al. 2012).
In the present work we focused on the most over-represented functional gene cluster, "NOTC Hsignaling" pathway, identified by submitting the list of the 104 genes with highly recurrent CNVs to the DAVID tool (http://david.abcc.ncifcrf.gov).abcc.ncifcrf.gov
Toroidal devices are the most highly developed.
To date, practically all IDH mutations found in cancer are heterozygous and highly recurrent.
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