Sentence examples for most highly mutated from inspiring English sources

This makes cSCC the most highly mutated human malignancy, compounding the difficulty in defining 'driver' molecular events underlying their development.

These studies estimated that the nsBMR from the set of genes remaining after the most highly mutated previously known driver genes were removed from the dataset.

Cutaneous SCC is the most highly mutated of all cancers, and consequently displays a complex genetic background (Durinck et al, 2011).

Frequency-based methods identify the most highly mutated genes in large-scale cancer sequencing efforts while bioinformatics approaches are effective for independent evaluation of both non-synonymous mutations and polymorphisms.

OmpJ (GSU3403) has 3-fold higher expression during growth on the electrode, and it was among the most highly mutated genes between the two strains, with 30 non-synonymous changes per kb (Additional file 1: Table S9).

Thus, although RASSF1A would not have been identified as an important RCC TSG by sequencing analysis alone, CDKN2A (which is mutated in approximately 10% of RCC and is the second most highly mutated gene in RCC [ 10]), is, on average, methylated in 11% of RCC [ 35, 36, 41, 43, 44, 55, 82], yielding a combined inactivation rate of about 21%.

With the exceptions of DNMT3B, which is significantly overexpressed in most cancer types studied here, and DNMT3A which is highly mutated in LAML, we do not see notable mutation rates or cancer-associated changes in expression level for DNMTs and HDACs (Additional file 2: Figure S1).

DCLK1 is among the 15 most common putative driver genes for gastric cancers and is highly mutated across various other human cancers.

Although not typically mutated in pancreatic cancer, Pten was highly mutated in two recent screens for gene mutations that accelerate KrasG12D-driven pancreatic tumorigenesis.

These genes are not selected by our method because they are mainly mutated in the highly mutated samples and the scores of the mutations are not high.

The tumor-suppressor gene p53 is highly mutated up to 50% in all human cancer types [1], making it the most genetically targeted gene involved in carcinogeneis.