ThiJ/PfpI protein family was among the most highly induced ESTs in the DON-induced library, being found 29 times.
We focused here on identifying the most highly induced TFs and their putative targets during human adipogenesis.
Among the most highly induced genes, there were a putative actin depolymerization factor, ADF, Os03g0820500 and an AWPM-19-like protein, AK102039 (Additional file 1: Figure S2a).
The gene most highly induced by amicoumacin A was lrgA, which encodes an antiholin-like product (LrgA) that appears in cells undergoing collapse of Δψ, and modulates murein hydrolase activity (Lama et al. 2012).
GEM-PU-PL12% most efficiently inhibited the proliferation of cholangiocarcinoma cells and most highly induced pro-inflammatory cytokines (TNF-α, IL-1β and IL-12) and p38 MAPKs in the cells.
The gene most highly induced by Wnt3a was GREMLIN2, which encodes a secreted BMP antagonist.
CXCL10 is one of the most highly induced cytokines during Th1-type inflammatory responses.
HSP70 is one of the most highly induced heat shock proteins in response to heat stress.
Note that of these mRNAs, CCN2 mRNA was the transcript that was most highly induced by TGFβ1.
Interestingly, the gene most highly induced by Wnt3a was GREMLIN2, which encodes a secreted bone morphogenetic protein (BMP) antagonist.
Interestingly, the top 50 of most highly induced genes contain a remarkably high number of established PPARα targets, regulation of which was conserved in mouse hepatocytes.
